Article

Article title TRANSFER OF THE INFORMATIONS SIGNALS IN SUBCELLULAR SYSTEMS
Authors Z. Kh.-M. Khashaev
Section SECTION IV. NEW INFORMATION TECHNOLOGIES
Month, Year 12, 2009 @en
Index UDC 577.3
DOI
Abstract Natural alkaloid drugs Glauchine, Stephaglabrine and Sanguiritrine, are shown to affect the synaptic transmission in a fairly complicatedmanner and seem to involve several different mechanisms of action. These substances as well as Berberine reduce amplitude of the spontaneous miniature end-plate potentials (MEPP) in a frog neuromuscular junction. At low concentrations all the mentioned alkaloids diminish frequency of MEPP, but increase it when their concentration exceeds a certain value. Sanguiritrine is the most active in this respect (hearly a 100-fold increase), that is probably associated with its uncoupling effect on the mitochondrial oxidative phosphorylation. Sanguiritrine and stephaglabrine both cause repeated muscle contracture if present at relatively high concentration.

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Keywords Synaptic transmission; miniature end-plate potentials; alkaloid drugs; uncoupling effect; subcellular system; oxidative phosphorylation.
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