Authors V.N. Vyazmitin, V.V. Polyakov
Month, Year 09, 2015 @en
Index UDC 621.38-022.532
Abstract The article provides the analysis of biological liquids in human organism and their properties. Describes contemporary methods of research and sampling samples for analysis, what the important by developing systems for personalized medicine. Revealed potential applications of microfluidics devices in modern systems of diagnostics and analysis, given description features and some parameters of blood corpuscles. Described the peculiarities and principles of construction of elements of microfluidic devices. Shown the relationship of the personalization of medicine and miniaturization of devices a modern micro- and nanotechnologies. Is noted that advanced system diagnostics and analysis are widely used microfluidics devices with chemical tests, cytometry, immunological analysis, clinical diagnostics and delivery of drugs in the body. This can be a variety of microchannels, micropumps, and inhalers, microreactors, etc. Dan calculation of the flow of fluid through the microchannels by a method of laminar flow. It is shown that laminar flow is possible only up to some critical value of the Reynolds number, after which it becomes turbulent. In addition, effect of hydrophobic and hydrophilic surfaces of microchannels was consider.By condition of "sticking" in microchannels of the fluid velocity is very small. Thus, the increase in speed requires a significant pressure, which can lead to the destruction of the channel. One of possible solution to this problem is the use of hydrophobic surfaces. In this case, for micro-fluidic devices on silicon, is used the oxidation of the surface of microchannels. The article stated that there are several ways of implementation of a system of channels on the chip: cross, double-T, double-L, double-cross, triple-T, multi-T, etc. Cross-system channel the most simple in realization and carrying out analyses. As an example, the realisation device for separation of biological liquids was shown example element formed by the method of local anodic oxidation. Was offer variant of the microfluidic device for separation of biological liquids.

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Keywords Microfluidic devices; technology; micro; nanotechnology; biosensors; classification.
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