Article

Article title METHODS OF PRELIMINARY BIOLOGICAL SENSOR SIGNAL PROCESSING IN ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY SYSTEMS
Authors L. K. Samoilov, E. A. Zhebrun
Section SECTION II. THE DESIGN OF THE CIRCUITRY
Month, Year 02, 2018 @en
Index UDC 621.317
DOI 10.23683/2311-3103-2018-2-142-154
Abstract The possibilities of creating specialized microelectronic systems of electrochemical impedance spectroscopy (EIS) as part of software and hardware systems based on biological sensors (BS) are considered. To increase the accuracy of the final value in such systems, a large (about 500) number of BS parallel channels are ensured. Users desire of obtaining a reliable result leading to the need to simultaneously conduct up to 500 analyzes of one substance. The question of the possibilities and limitations of EIS systems in the context of modern technological advances has been explored. The paper shows that effective multi-channel EIS systems can be built in the form of systems on a chip within the framework of standard CMOS process technology. In EIS systems with a comparatively low frequency of BS operating signals (up to 20 kHz) integrating ADCs are widely used. Its input circuits are optimally combined with the BS outputs and allow the operation of digital multiplication to be performed on a digital signal. In integrating ADCs, according to the limiting factors considered in the work, it is possible to optimize the characteristics depending on the final requirements. Within the framework of the modern 90 nm process technology, the main blocks of the integrating ADCs – integrator and the comparator are designed. The circuit solutions allow us to expand the freedom of parameters choice in the space of the variable clock frequency, conversion speed and conversion accuracy. So, for example, it is possible to create an analog signals input device based on an integrating converter with an accuracy of 10 bits at 1 MHz frequency conversion at a clock frequency of 5 GHz. At the same time, for one channel of BS analog interface, the power is reduced to tens of microwatts and the area on the crystal is up to 0.05 mm2, that allows to reach high integration in multi-channel EIS systems based on integrating ADSs with a large number of BSs. The used technological process is provided by one of the leaders of the homeland microelectronics market PJSC "Mikron" (Moscow). This allows us to use the demonstrated circuit engineering developments in import substitution programs.

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Keywords Data processing module; biological sensor; impedance spectroscopy; analog-to-digital converter; integrator; comparator.
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